[The tolerance dose of the urinary bladder].

Area of Science:

• Radiation oncology
• Medical physics
• Uro-oncology

Context:

• Assessing late urinary bladder injury in patients undergoing radiotherapy for bladder and cervical cancers.
• Evaluating different radiotherapy techniques including external beam, conformation radiotherapy, arc therapy, and intracavitary irradiation.
• Analyzing data from 79 bladder cancer patients and 308 cervical cancer patients.

Purpose:

• To determine the tolerance dose of the urinary bladder in patients treated for various pelvic malignancies.
• To establish dose-response relationships for late urinary bladder toxicity based on treatment modality.
• To provide evidence-based tolerance dose recommendations for optimizing radiotherapy planning.

Summary:

• Radiotherapy for bladder cancer showed a urinary bladder tolerance dose as low as 100 TDF (Time-Dose-Fractionation).
• Cervical cancer patients treated with conformation or arc therapy plus low-dose rate brachytherapy had a tolerance dose of 110-120 TDF.
• Cervical cancer patients treated primarily with low-dose rate brachytherapy and whole pelvic irradiation exhibited a tolerance dose of 120 TDF or higher.

Impact:

• Informs radiation oncologists on bladder dose constraints for improved treatment planning.
• Contributes to reducing late urinary toxicity in pelvic cancer radiotherapy.
• Supports the development of safer and more effective radiation protocols for gynecological and urological cancers.