Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Conserved Mammalian Hippocampal Navigation Motif Reconfigured for Primate Vision.

bioRxiv : the preprint server for biology·2026

Same author

Intrinsic neuronal diversity as a substrate for cortical area specialization in primate vision.

Nature communications·2026

Same author

The Visual Umwelt of primates and Hippocampal Representations of Space.

Hippocampus·2025

Same author

The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space.

Imaging neuroscience (Cambridge, Mass.)·2025

Same author

Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.

Communications biology·2025

Same author

Bilateral Field Advantage of Spatial Attention in Macaque Lateral Prefrontal Cortex.

Journal of cognitive neuroscience·2025

Same journal

Ultra-flexible wireless endovascular stimulator for cortical simulation.

Journal of neural engineering·2026

Same journal

Influence of frequency and pulse train duration on respiratory responses during transcutaneous phrenic nerve stimulation in humans.

Journal of neural engineering·2026

Same journal

Dynamic functional graph-Laplacian priors integrated with optimization for EEG source localization.

Journal of neural engineering·2026

Same journal

Unveiling subject-specific causal latency in motor imagery: a physiologically transparent BCI via Riemannian tangent space fusion.

Journal of neural engineering·2026

Same journal

Cross-subject decoding of human neural data for speech Brain Computer Interfaces.

Journal of neural engineering·2026

Same journal

Cognitive and brain function enhancement in Gen X group after personalized, AI supervised EEG-neurofeedback training.

Journal of neural engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 13, 2025

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

Decoding spatial locations from primate lateral prefrontal cortex neural activity during virtual navigation.

Renée Johnston^1,2, Mohamad Abbass^3,4,5, Benjamin Corrigan^4,5

¹University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.

Journal of Neural Engineering

|January 24, 2023

Summary

This summary is machine-generated.

Brain signals from the lateral prefrontal cortex (LPFC) can predict navigation paths in virtual environments. This finding supports using the LPFC for brain-computer interfaces to aid mobility in patients with disabilities.

Keywords:

invasive brain-computer interface lateral prefrontal cortex non-human primates spatial navigation support vector machine

More Related Videos

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Aug 13, 2025

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Area of Science:

Neuroscience
Biomedical Engineering
Cognitive Science

Background:

Brain-computer interfaces (BCIs) offer potential for restoring mobility in individuals with disabilities.
Decoding intended movement trajectories from neural signals is a key challenge in BCI development.

Purpose of the Study:

To investigate the feasibility of using neural activity from the lateral prefrontal cortex (LPFC) to predict spatial navigation trajectories.
To establish proof of principle for LPFC as a target area for brain-computer interface systems.

Main Methods:

Recorded multi-unit spiking activity from the LPFC of macaques during a virtual navigation task.
Utilized a support vector machine model to decode spatial locations from neural data.

Main Results:

Multi-unit spiking activity in the LPFC successfully predicted subject locations within a virtual maze.
Predictive accuracy was higher for locations involving choices or task-relevant events.
Multiple maze locations were independently identifiable within a single trial epoch.

Conclusions:

The LPFC contains neural information predictive of spatial navigation.
The LPFC's shared properties between macaques and humans suggest its potential as an implant site for spatial navigation BCIs.
This research supports the development of BCIs for enhancing mobility in patients with disabilities.