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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss
Aidan B Jackson1, Keith R Martin2, Michael A Coote1
1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.
Ophthalmology
|January 24, 2023
Summary
Approximately 1 in 8 glaucoma patients show fast vision loss globally, and nearly 1 in 3 experience central vision decline. Early detection and new therapies are crucial for managing glaucoma progression.
Area of Science:
- Ophthalmology
- Vision Science
- Glaucoma Research
Background:
- Glaucoma is a leading cause of irreversible blindness worldwide.
- Routine care aims to slow glaucoma progression, but fast progression remains a concern.
- Assessing visual field (VF) progression is critical for managing glaucoma patients.
Purpose of the Study:
- To determine the prevalence of fast global and central visual field (VF) progression in individuals with glaucoma under routine care.
- To quantify the rates of change in mean deviation (MD) and central 10° mean total deviation (MTD10).
Main Methods:
- An observational study involving 693 eyes of 461 glaucoma patients over a median of 4.5 years.
- Data collected from a private clinic in Australia and two US-based longitudinal studies.
- Ordinary least squares regression analyzed global MD and central MTD10 changes.
Main Results:
- 12.5% of eyes showed fast global progression (MD < -1.0 dB/year).
- 29.0% of eyes exhibited significant central progression (MTD10 < -0.5 dB/year).
- 12.7% and 9.1% of eyes exceeded the 1% normal distribution cutoff for MD and MTD10, respectively.
Conclusions:
- A significant proportion of glaucoma patients under routine care experience fast global and central VF progression.
- Findings underscore the importance of monitoring central VF loss and developing novel therapies.
- Early identification of rapid progression is key to preventing functional vision loss.
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