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Updated: Aug 12, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast
S M Nashir Udden1, GuemHee Baek2, Kamal Pandey1
1Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Abstract:
Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.
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