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Homozygous-Recessive Characteristics as a Biomarker of Predisposition for COVID-19

Darko Grujičić1, Ljiljana Mirkov2, Dragić Banković1

  • 1University of Kragujevac, Serbia.

Clinical Nursing Research
|January 25, 2023
PubMed

Insights

The homozygous-recessive characteristics (HRC) test may identify individuals predisposed to severe COVID-19. Higher HRC scores correlated with increased COVID-19 risk and disease severity.

Area of Science:

  • Genetics
  • Epidemiology
  • Infectious Diseases

Background:

  • Coronavirus disease (COVID-19) emerged as a global pandemic.
  • Understanding genetic predispositions is crucial for managing infectious diseases.

Purpose of the Study:

  • To analyze homozygous-recessive characteristics (HRC) in COVID-19 patients.
  • To investigate the association between HRC and disease severity, risk factors, and demographic factors.

Main Methods:

  • A sample of 321 individuals (205 COVID-19 patients, 116 controls) was analyzed.
  • Twenty homozygous-recessive characteristics (HRCs) were assessed using the HRC test.
  • Statistical analysis was performed to compare HRC between patients and controls, and across different disease severity levels.

Main Results:

  • COVID-19 patients exhibited significantly higher average HRC compared to controls.
  • Patients with severe COVID-19 symptoms had higher HRC than those with mild symptoms.
  • A higher HRC (cut-off ≤5.5) was associated with a 2.3-fold increased risk of COVID-19 (OR = 2.315, p < .0005).

Conclusions:

  • The HRC test may serve as a valuable screening tool for identifying COVID-19 predisposition.
  • Homozygous-recessive characteristics are linked to increased risk and severity of COVID-19.

Keywords:
COVID-19genetic predispositionhomozygous-recessive characteristics

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