Related Experiment Video

Updated: Aug 12, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

6.9K

Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators

Sayuri Takahashi1,2, Ichiro Takada1

  • 1Department of Urology, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Asian Journal of Andrology
|January 25, 2023
PubMed

Insights

This review explores how noncanonical WNT signaling and chromatin remodelers influence prostate cancer progression. Understanding these molecular mechanisms is crucial for developing new treatments for castration-resistant prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Prostate cancer is a leading cause of cancer death in men globally.
  • Castration-resistant prostate cancer (CRPC) presents a significant therapeutic challenge.
  • Elucidating molecular mechanisms is key to developing novel CRPC drugs.

Purpose of the Study:

  • To review the roles of noncanonical WNT signaling pathways in prostate cancer.
  • To examine the involvement of chromatin remodelers in prostate cancer progression.
  • To discuss the impact of epigenetic enzymes on prostate cancer development.

Main Methods:

  • Literature review of noncanonical WNT signaling in prostate cancer.
  • Analysis of the role of chromatin remodelers (e.g., SWI/SNF) in gene regulation.
  • Investigation of epigenetic enzymes in prostate cancer pathogenesis.

Main Results:

  • Noncanonical WNT signaling, particularly WNT5A, is implicated in prostate cancer progression and metastasis, though its role is debated.
  • Chromatin remodelers like SWI/SNF influence prostate cancer through genome-wide gene expression changes.
  • Epigenetic modifications are critical regulators of prostate cancer development.

Conclusions:

  • Noncanonical WNT pathways and chromatin remodelers are vital in prostate cancer.
  • Targeting these pathways may offer new therapeutic strategies for CRPC.
  • Further research into epigenetic regulation is needed for effective prostate cancer treatment.
Keywords:
WNT5Achromatin remodelinghistone-modifying enzymesprostate cancer

More Related Videos

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

8.8K
Murine Prostate Micro-dissection and Surgical Castration08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

45.9K

Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K