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Published on: May 26, 2019
Copper-Catalyzed Regioselective Remote C-H Bond Chalcogenation of Aromatic Amine Derivatives without Using Any Large
Biprajit Paul1, Surajit Das1, Indranil Chatterjee1
1Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab 140001, India.
Abstract:
A mild and convenient strategy has been developed for the para-selective chalcogenation of anilide scaffolds via C-H bond functionalization. This methodology employs one of the most earth-abundant and inexpensive Cu(II) catalysts and a commercially available simple aryl chalcogen source without any complex directing template, exogenous ligand, acid/base, oxidant, or other additives. The key feature of this methodology is an impressive regioselectivity along with a wide range of functional group tolerance with good to excellent yields under aerobic conditions.
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