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Updated: Aug 12, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Childhood Interstitial Lung Disease

Halime Nayir Buyuksahin1, Nural Kiper1

  • 1Department of Pediatric Pulmonology, School of Medicine, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

Pediatric Allergy, Immunology, and Pulmonology
|January 25, 2023
PubMed

Insights

Childhood interstitial lung disease (chILD) diagnosis is improving with increased awareness and genetic testing. A systematic approach helps avoid invasive procedures and guides targeted therapies for these rare lung conditions.

Area of Science:

  • Pediatric Pulmonology
  • Rare Diseases
  • Medical Diagnostics

Background:

  • Childhood interstitial lung disease (chILD) is a complex group of rare lung disorders.
  • chILD incidence and prevalence are rising due to better understanding and physician awareness.
  • Nonspecific symptoms like tachypnea, hypoxemia, and cough are common in chILD.

Purpose of the Study:

  • To present a systematic, patient-centered diagnostic approach for chILD.
  • To highlight the role of genetic testing and imaging in chILD diagnosis.
  • To emphasize the importance of recognizing pulmonary involvement in systemic diseases.

Main Methods:

  • Systematic review of diagnostic strategies for chILD.
  • Emphasis on non-invasive diagnostic tools like genetic examination and computed tomography (CT) imaging.
  • Integration of clinical findings with diagnostic modalities.

Main Results:

  • Genetic testing can identify specific mutations, aiding diagnosis and avoiding invasive procedures.
  • Typical CT imaging patterns can facilitate early chILD recognition.
  • Pulmonary manifestations in systemic diseases, including connective tissue diseases, require consideration.

Conclusions:

  • A systematic diagnostic approach is crucial for effectively managing chILD.
  • Advances in genetic analysis and imaging improve diagnostic accuracy and patient outcomes.
  • International collaboration is enhancing knowledge and targeted therapies for chILD.

Keywords:
childrencomputed tomographygenetic testsinterstitiallung disease

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