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Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy

Mohamad Hamad1, Dana M H AlKhamach2, Lujain Majed Alsayadi2

  • 1College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Viral Immunology
|January 25, 2023
PubMed

Insights

New severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threaten public health by reducing vaccine and therapeutic effectiveness. Understanding these mutations is crucial for managing the ongoing pandemic.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has seen global expansion.
  • Emergence of SARS-CoV-2 variants poses a significant public health challenge.

Purpose of the Study:

  • To evaluate SARS-CoV-2 variants of concern.
  • To assess the impact of variants on vaccine and therapeutic effectiveness.

Main Methods:

  • Extensive literature search.
  • In-depth analysis of scientific data.

Main Results:

  • Significant mutations have evolved in SARS-CoV-2 variants.
  • Variants can reduce vaccine efficacy and antibody neutralization.
  • Therapeutic efficiency is limited by viral mutations.

Conclusions:

  • SARS-CoV-2 variants present a serious threat to public health.
  • Mutations impact vaccine and therapeutic strategies.
  • Predicting future impacts guides selection of effective countermeasures.
Keywords:
OmicronSARS-CoV-2therapiesvaccinesvariants of concern

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