Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

155
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
155
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

898
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
898
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

960
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
960
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

159
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
159
Key Techniques in Microbiology01:29

Key Techniques in Microbiology

177
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
177

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials.

ACS infectious diseases·2026
Same author

Repurposing Clinical Candidates for Nipah and Hendra Viruses.

ACS infectious diseases·2026
Same author

Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study.

ACS omega·2026
Same author

Distributed Capability, Shared Vulnerability: International Governance of Biosafety and Biosecurity.

Cold Spring Harbor perspectives in medicine·2026
Same author

Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates.

Journal of xenobiotics·2026
Same author

MegaEye: Applying multiple machine learning approaches to identify oral compounds with ocular bioactivity.

Artificial intelligence in the life sciences·2026
Same journal

Mapping Evolution of Molecules across Biochemistry with Assembly Theory.

Journal of chemical information and modeling·2026
Same journal

Structural Proteomics-Based Deciphering of Hydrophobic Packing Fingerprints Informing Protein Thermostability in TIM Barrels.

Journal of chemical information and modeling·2026
Same journal

Bridging between Structure-Based and Data-Driven Affinity Prediction.

Journal of chemical information and modeling·2026
Same journal

Reinforcement Learning-Driven Multiproperty Optimization in Molecular Design Using Multicontext Transcriptome Data.

Journal of chemical information and modeling·2026
Same journal

EnsembleCycPerm: Interpretable Modeling of Cyclic Peptide Permeability through Solvent-Dependent Conformational Ensembles.

Journal of chemical information and modeling·2026
Same journal

Resolving Conformational Preferences of Monosaccharides from <sup>1</sup>H and <sup>13</sup>C NMR Chemical Shifts Using an Integrated MD and QM Approach.

Journal of chemical information and modeling·2026
See all related articles

Related Experiment Video

Updated: Aug 12, 2025

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

8.8K

Preventing AI From Creating Biochemical Threats.

Fabio Urbina1, Filippa Lentzos2, Cédric Invernizzi3

  • 1Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.

Journal of Chemical Information and Modeling
|January 25, 2023
PubMed
Summary
This summary is machine-generated.

Machine learning models can design chemical warfare agents, highlighting the need for robust biosecurity measures. This viewpoint proposes 10 recommendations to prevent future biochemical threats and mitigate risks.

More Related Videos

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

14.7K
Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence
09:11

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Published on: January 27, 2023

2.2K

Related Experiment Videos

Last Updated: Aug 12, 2025

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

8.8K
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

14.7K
Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence
09:11

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Published on: January 27, 2023

2.2K

Area of Science:

  • Computational chemistry
  • Biosecurity
  • Toxicology

Background:

  • Machine learning models for bioactivity and toxicity were previously developed.
  • A generative algorithm was used in conjunction with these models.

Purpose of the Study:

  • To discuss the ease of designing chemical warfare agents.
  • To propose 10 recommendations to prevent future biochemical threats.

Main Methods:

  • Application of machine learning models for bioactivity and toxicity prediction.
  • Utilization of a generative algorithm for analogue development.

Main Results:

  • Demonstrated the capability to design VX and numerous analogues.
  • Highlighted the accessibility of designing chemical warfare agents.

Conclusions:

  • The ease of designing chemical warfare agents necessitates proactive biosecurity strategies.
  • 10 actionable recommendations are presented to prevent future biochemical threats.