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Multiresistant Candida Endophthalmitis Treated with Intravitreal Caspofungin: A Case Report

Marta Garrido-Marin1, Eric Kirkegaard Biosca1, Anna Boixadera1

  • 1Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Ocular Immunology and Inflammation
|January 25, 2023
PubMed
Abstract

Insights

Intravitreal caspofungin offers a potential alternative for treating resistant Candida endophthalmitis. This case study explores its use alongside vitrectomy for bilateral fungal eye infections.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Candida endophthalmitis is a serious complication of candidemia.
  • Standard treatment involves systemic and intravitreal antifungals, sometimes with vitrectomy.
  • Intravitreal caspofungin use is emerging but clinical data remains limited.

Observation:

  • A case of bilateral Candida tropicalis endophthalmitis is presented.
  • Initial management included repeated intravitreal caspofungin injections (100 μg/0.1 ml).
  • Subsequent treatment involved pars plana vitrectomy in both eyes.

Findings:

  • Intravitreal caspofungin demonstrated potential as a treatment modality.
  • The combination with vitrectomy was necessary for managing this severe bilateral case.

Implications:

  • Intravitreal caspofungin may serve as a safe alternative for resistant fungal endophthalmitis.
  • Further research is warranted to establish its efficacy and safety profile.
  • This case contributes to the limited clinical experience with intravitreal caspofungin.
Keywords:
Candidacase reportcaspofunginendophthalmitisintravitreal

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