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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Multiresistant Candida Endophthalmitis Treated with Intravitreal Caspofungin: A Case Report
Marta Garrido-Marin1, Eric Kirkegaard Biosca1, Anna Boixadera1
1Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Ocular Immunology and Inflammation
|January 25, 2023
Summary
Intravitreal caspofungin offers a potential alternative for treating resistant Candida endophthalmitis. This case study explores its use alongside vitrectomy for bilateral fungal eye infections.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Candida endophthalmitis is a serious complication of candidemia.
- Standard treatment involves systemic and intravitreal antifungals, sometimes with vitrectomy.
- Intravitreal caspofungin use is emerging but clinical data remains limited.
Observation:
- A case of bilateral Candida tropicalis endophthalmitis is presented.
- Initial management included repeated intravitreal caspofungin injections (100 μg/0.1 ml).
- Subsequent treatment involved pars plana vitrectomy in both eyes.
Findings:
- Intravitreal caspofungin demonstrated potential as a treatment modality.
- The combination with vitrectomy was necessary for managing this severe bilateral case.
Implications:
- Intravitreal caspofungin may serve as a safe alternative for resistant fungal endophthalmitis.
- Further research is warranted to establish its efficacy and safety profile.
- This case contributes to the limited clinical experience with intravitreal caspofungin.
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