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Anti-Bacteroides fragilis substance from rhubarb
J Cyong1, T Matsumoto, K Arakawa
1Oriental Medicine Research Center, Kitasato Institute, Tokyo, Japan.
Journal of Ethnopharmacology
|May 1, 1987
Summary
Rhubarb root (Rheum officinale) extract demonstrated significant antibacterial activity against Bacteroides fragilis. The active compound responsible for this effect was identified as rhein, a key finding for gut flora research.
Area of Science:
- Microbiology
- Pharmacology
- Natural Products Chemistry
Background:
- Bacteroides fragilis is a dominant anaerobic bacterium in the human gut microbiome.
- Understanding its susceptibility to natural compounds is crucial for gut health.
- Screening traditional Chinese herbs offers potential for novel antibacterial agents.
Purpose of the Study:
- To screen extracts from 178 Chinese herbs for antibacterial activity against Bacteroides fragilis.
- To identify specific herbs and compounds with potent inhibitory effects.
Main Methods:
- Antibacterial screening of 178 Chinese herbal extracts.
- Microbiological assays to determine activity against Bacteroides fragilis.
- Purification and identification of the active antibacterial compound.
Main Results:
- Only rhubarb root (Rheum officinale) extract exhibited significant antibacterial activity.
- The purified active substance was identified as rhein.
- Rhein shows specific inhibitory action against Bacteroides fragilis.
Conclusions:
- Rheum officinale possesses significant antibacterial properties against Bacteroides fragilis.
- Rhein is the primary active compound in rhubarb root responsible for this activity.
- This study highlights the potential of rhubarb and rhein as natural agents for modulating gut microbiota.