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Chemistry and pharmacology of a tertiary alkaloid from Strychnos trinervis root bark
M F Melo1, C A Santos, A A Chiappeta
1Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Brazil.
Journal of Ethnopharmacology
|May 1, 1987
Abstract:
Bisnordihydrotoxiferine has been isolated as the major alkaloid from the root bark of Strychnos trinervis. This compound shows a wide antimicrobial spectrum against gram-positive, gram-negative and acid-fast microorganisms, filamentous and yeast-like fungi and also phytopathogenic microorganisms. Preliminary studies also reveal some cytotoxic activity in KB cells which was confirmed by tests against sarcoma 180 tumors.