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The influence of different glucose tolerance on QTc interval: a population-based study
Ning Lin1,2, Hongmei Zhang1, Xiaoyong Li1
1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abnormal glucose regulation, including impaired glucose tolerance and type 2 diabetes, is linked to longer corrected QT (QTc) intervals in older Chinese adults. This suggests glucose metabolism can help monitor QTc intervals.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- The corrected QT (QTc) interval, a measure of cardiac repolarization, has been previously associated with type 2 diabetes.
- Understanding the relationship between glucose metabolism and QTc intervals is crucial for cardiovascular risk assessment.
Purpose of the Study:
- To investigate the association between varying glucose tolerance levels and QTc intervals in a Chinese population of middle-aged and older adults.
- To explore the potential of glucose regulation status as a marker for QTc interval changes.
Main Methods:
- A cross-sectional analysis of 9898 Chinese individuals (3194 men, 6704 women) was performed.
- Glucose tolerance was assessed using an oral glucose tolerance test (OGTT).
- ECG recordings were used to determine QTc intervals, with participants stratified by glucose tolerance status.
Main Results:
- Subjects with abnormal glucose metabolism exhibited significantly increased QTc interval levels compared to those with normal glucose regulation.
- Multiple regression analyses revealed significant associations between QTc interval and fasting plasma glucose, 2-h OGTT plasma glucose, and HbA1c.
- The odds ratio for prolonged QTc was 1.396 for impaired glucose regulation (IFG/IGT) and 1.342 for type 2 diabetes after adjusting for confounders.
Conclusions:
- Impaired glucose tolerance and type 2 diabetes are significantly associated with prolonged QTc intervals in middle-aged and older Chinese individuals.
- Abnormal glucose regulation may serve as a valuable indicator for monitoring QTc intervals within the population.
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