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Vaccine-induced immune thrombotic thrombocytopenia (VITT) after SARS-CoV-2 vaccination: Two cases from Germany with

Rhea Edmonds1,2, Linda Schönborn3, Sunke Habben1,2

  • 1Department of Gastroenterology, Endocrinology, Diabetology and General Medicine Klinikum Kassel Kassel Germany.

Clinical Case Reports
|January 26, 2023
PubMed

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare clinical condition that has emerged during the mass immunization against SARS-CoV-2. Reports indicate that VITT may also be induced by other vaccines, such as the human papillomavirus vaccine, or occur independently of vaccination. Its recognition requires a high index of suspicion, especially in patients presenting with thrombocytopenia and thrombosis several days after vaccination with an adenoviral vector-based vaccine against SARS-CoV-2. Bleeding manifestations do not exclude VITT, as initially assumed. It is of great importance to perform the appropriate diagnostic tests early in the course of the disease, as false-negative results may occur and many aspects of VITT are not fully understood. These two cases from Germany demonstrate unusual presentations of VITT.

Keywords:
COVID‐19SARS‐CoV‐2 vaccinationvaccine‐induced immune thrombocytopenia and thrombosis

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