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OmicsTIDE: interactive exploration of trends in multi-omics data.

Theresa A Harbig1, Julian Fratte1, Michael Krone1

  • 1Institute for Bioinformatics and Medical Informatics, University of Tuebingen, Tuebingen 72076, Germany.

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Summary

OmicsTIDE visualizes multi-omics data trends, enabling researchers to understand individual omics layer impacts. This interactive tool aids in comparing gene expression patterns across datasets for deeper biological insights.

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Area of Science:

  • * Computational Biology
  • * Bioinformatics
  • * Systems Biology

Background:

  • * Increasing multi-omics data necessitates advanced analytical tools.
  • * Existing visualization tools often lack the ability to isolate the influence of individual omics layers.
  • * A systemic understanding of multi-omics data integration remains a challenge.

Purpose of the Study:

  • * To develop a novel data classification scheme for multi-omics datasets.
  • * To create an interactive visualization tool, OmicsTIDE, for comparing gene-based quantitative omics data.
  • * To enable the reconstruction of single omics layer impacts on integrated analysis results.

Main Methods:

  • * Development of a data classification scheme for multi-omics datasets.
  • * Implementation of OmicsTIDE, featuring a computational clustering component and interactive visualization.
  • * Utilization of profile plots and Sankey diagrams for trend visualization and pairwise comparison.
  • * Integration of Gene Ontology enrichment for functional analysis of data subsets.

Main Results:

  • * OmicsTIDE effectively clusters omics datasets to identify and visualize trends.
  • * The tool facilitates interactive pairwise comparison of trends, highlighting concordant and discordant patterns.
  • * OmicsTIDE enables functional analysis of large datasets by breaking them into manageable subsets.
  • * Case studies demonstrate the tool's utility in analyzing diverse experimental designs.

Conclusions:

  • * OmicsTIDE provides a novel approach for interactive multi-omics data exploration and comparison.
  • * The tool enhances transparency in multi-omics analysis by visualizing individual layer contributions.
  • * OmicsTIDE supports a systemic understanding of complex biological phenomena through integrated data analysis.