Bibliometric evaluation of 2011-2021 publications on hydrogen sulfide in heart preservation research

Hydrogen sulfide (H₂S) is known for its unpleasant odor and severe toxicity. However, an in-depth study of H₂S showed that it can be used as an important messenger, which can play important physiological and pathological roles in vitro and in vivo. In recent years, the application of H₂S in the field of cardiac preservation has attracted the interest and attention of scholars worldwide. H₂S plays an effective and protective role in cardiac ischemia/reperfusion injury through antioxidant, anti-inflammatory, and antiapoptotic mechanisms.

The purpose of this study is to analyze the current scientific achievements on the application of H₂S in the field of cardiac preservation and to provide new ideas for further research.

TS = ("hydrogen sulfide" OR "hydrogen sulfide") AND TS = ("cardiac" OR "heart" OR "myocardium" OR "hearts") AND TS = ("reperfusion" or "transplantation" or "implanted" or "transplant" or "implantation" or "migration" or "preservation" or "grafting" OR "ischemia" OR "perfusion" or "conservation" or "preserve" or "reservation") AND DT = (Article OR Review) AND LA = (English) were used as search strategies for data collection from the Science Citation Index-Expanded database of the Web of Science Core Collection. CiteSpace 5.8. R3 and Microsoft Office Excel 2019 were used for data analysis.

A total of 429 related articles were included, and the total number of articles showed a fluctuating upward trend. We used CiteSpace 5.8. R3 and Microsoft Excel 2019 to evaluate and visualize the results, analyzing institutions, countries, journals, authors, co-cited references, and keywords.

As increasing evidence shows that H₂S plays an indispensable role in the field of cardiac preservation, its mechanistic research and clinical application may become the main focus of future research.