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Nitric oxide and thyroid carcinoma: A review

Yu Huang1, Rinkiko Suguro2, Wei Hu2

  • 1School of Pharmacy, Macau University of Science and Technology, Macau, Macau SAR, China.

Frontiers in Endocrinology
|January 26, 2023
PubMed

Insights

Nitric oxide (NO), a signaling molecule, plays a complex role in thyroid cancer development. Understanding its dual function is key to developing novel prevention and treatment strategies for this common endocrine cancer.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Thyroid carcinoma is the most common endocrine cancer globally, with increasing incidence.
  • Current therapies for thyroid cancer have seen limited recent improvement, highlighting an unmet need for novel treatments.

Purpose of the Study:

  • To review the role and molecular mechanisms of nitric oxide (NO) in thyroid carcinoma.
  • To discuss the potential of NO in the prevention and treatment of thyroid carcinoma.

Main Methods:

  • Literature review of studies on nitric oxide (NO) and cancer.
  • Analysis of NO's effects on angiogenesis, apoptosis, cell cycle, invasion, and metastasis in cancer.
  • Focused review on the relationship between NO and thyroid carcinoma.

Main Results:

  • Nitric oxide (NO) is synthesized by nitric oxide synthase (NOS) and acts as a signaling molecule.
  • NO has a dual role in cancer, capable of both promoting and inhibiting tumor development.
  • NO influences key cancer processes including angiogenesis, apoptosis, cell cycle, invasion, and metastasis.

Conclusions:

  • Nitric oxide (NO) significantly impacts thyroid carcinoma through various molecular mechanisms.
  • Further research into NO's complex role may unlock new avenues for thyroid cancer prevention and therapy.
Keywords:
eitric oxide synthaseendocrine systemnitric oxidethyroid carcinomatreatment

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