Related Experiment Video

Updated: Aug 12, 2025

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
05:51

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes

Published on: November 3, 2023

6.4K

MECHANICAL VENTILATION NEED AND GLYCEMIC STATUS IN PATIENTS WITH COVID -19: A FOLLOW-UP STUDY

S Taş1, Ü Taş1

  • 1Manisa City Hospital, Department of Cardiology, Manisa Merkezefendi State Hospital, Department of Cardiology, Manisa, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)
|January 26, 2023
PubMed

Insights

Prediabetes significantly impacts COVID-19 outcomes, increasing the need for mechanical ventilation and impairing cardiac function similarly to diabetes. This suggests prediabetes warrants similar risk stratification in COVID-19 patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Infectious Diseases

Background:

  • Diabetes mellitus is a known risk factor for severe COVID-19.
  • Limited data exists on the association between prediabetes and COVID-19 outcomes.
  • Understanding prediabetes's impact is crucial for comprehensive patient risk assessment.

Purpose of the Study:

  • To evaluate the effect of prediabetes and mechanical ventilation on COVID-19 course.
  • To determine cardiac function and laboratory changes in recovered COVID-19 patients.
  • To compare outcomes across normoglycemic, prediabetic, and diabetic COVID-19 patients.

Main Methods:

  • Study included 87 adult COVID-19 inpatients (April-August 2021).
  • Patients were grouped into normoglycemia (n=40), prediabetes (n=25), and diabetes (n=22).
  • Analyses compared laboratory, echocardiographic findings, and COVID-19 outcomes, including mechanical ventilation need.

Main Results:

  • Prediabetes and diabetes groups required significantly more mechanical ventilation than normoglycemic patients.
  • Both prediabetes and diabetes groups showed impaired left ventricular (LV) and right ventricular (RV) diastolic function (e.g., higher LV E/Em, RV MPI).
  • Mechanical ventilation was associated with elevated inflammatory markers (CRP, ferritin), cardiac biomarkers (troponin), and altered glucose/lipid profiles.

Conclusions:

  • Prediabetes is linked to impaired cardiac diastolic function in COVID-19 patients, comparable to diabetes.
  • Prediabetes should be considered in risk stratification for COVID-19 patients, similar to diabetes.
  • Further research on cardiac and laboratory changes post-COVID-19 recovery in prediabetic individuals is warranted.
Abstract

Keywords:
Covid-19PrediabetesRight Ventricular Dysfunction

More Related Videos

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

3.4K
Improving IV Insulin Administration in a Community Hospital12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.9K

Related Concept Videos

Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
668
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
169
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
196
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
287
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K