THE EFFECTS OF CHRONIC PERIODONTITIS AND OBESITY ON TOTAL ANTIOXIDANT/OXIDANT STATUS AND OXIDATIVE STRESS INDEX

Area of Science:

• Oral Health
• Metabolic Disorders
• Biochemistry

Background:

• Obesity and periodontal disease are prevalent global health issues.
• Emerging research suggests a potential link between obesity and periodontal disease.
• Understanding the pathophysiological relationship is crucial for public health.

Purpose of the Study:

• To investigate the pathophysiological relationship between obesity and periodontal disease.
• To evaluate clinical periodontal parameters and oxidative status in relation to obesity and periodontitis.
• To assess local and systemic oxidative stress markers.

Main Methods:

• Study included 80 participants divided into four groups: healthy normal weight, chronic periodontitis normal weight, healthy obese, and chronic periodontitis obese.
• Clinical periodontal parameters were recorded.
• Serum, saliva, and gingival crevicular fluid (GCF) samples were analyzed for total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).

Main Results:

• No significant differences in TAS, TOS, or OSI were observed in serum and saliva samples across the groups.
• GCF-TAS was significantly higher in the healthy normal weight group compared to others.
• GCF-TOS levels were significantly elevated in obese groups (healthy obese and chronic periodontitis obese) compared to non-obese groups.

Conclusions:

• Obesity and chronic periodontitis do not appear to affect systemic (serum) or salivary oxidant/antioxidant levels.
• Localized oxidative stress, indicated by increased GCF-TOS, may be associated with obesity.
• Confounding factors like lifestyle and nutrition could influence oxidative stress parameters and require further standardization in future studies.