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Related Concept Videos

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Related Experiment Video

Updated: Aug 12, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Decrease in Mortality from Sepsis: Impact of the Multidisciplinary Program for the Hematologic Patient at Very High

Ana L Basquiera1,2, María A Aguirre3, Florencia A Serra3

  • 1Hematology Section, Department of Internal Medicine, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Perón 4190, C1199ABB Buenos Aires, Argentina.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|January 26, 2023
PubMed
Summary

A new program significantly reduced sepsis-related mortality in high-risk hematologic patients. This initiative focused on preventing multidrug-resistant organism infections through a multidisciplinary approach and preventive measures.

Keywords:
Acute myeloid leukemiaMortalityMultidrug-resistant organismsSepsisStem cell transplantation

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A Data-Driven Approach to Quantifying Immune States in Sepsis
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Area of Science:

  • Infectious Diseases
  • Hematology
  • Critical Care Medicine

Background:

  • Hematologic patients face a high risk of infections, particularly from multidrug-resistant organisms (MDROs).
  • Sepsis and MDRO colonization pose significant threats to patient outcomes in this vulnerable population.

Purpose of the Study:

  • To evaluate the effectiveness of a multidisciplinary program (HAR) in reducing MDRO infections and sepsis-related mortality.
  • To assess the program's impact on specific MDROs like carbapenemase-producing Klebsiella pneumoniae and multidrug-resistant Pseudomonas aeruginosa.

Main Methods:

  • Retrospective comparison of pre-HAR (2016-2018) and post-HAR (2018-2019) periods.
  • Inclusion of 262 patients undergoing hematopoietic stem cell transplant (HSCT) or intensive chemotherapy for acute myeloid leukemia (CH-AML).
  • Analysis of MDRO infection rates and sepsis-related mortality.

Main Results:

  • MDRO infections occurred in 4.6% at 30 days and 6.1% at 90 days, exclusively during the pre-HAR period.
  • Overall sepsis-related mortality was 6.5% (median follow-up 608 days).
  • Sepsis-related mortality decreased from 8.7% in the pre-HAR period to 0% in the post-HAR period (p=0.014).

Conclusions:

  • The HAR program, integrating preventive measures and judicious antibiotic use, effectively decreased sepsis-related mortality.
  • A multidisciplinary approach is crucial for managing infections in very high-risk hematologic patients.
  • The program demonstrated success in controlling MDRO infections and improving survival outcomes.