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Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
Jing Li1,2, Chang-Yu Qiu1,3, Yue-Jin Tao2
1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Frontiers in Genetics
|January 26, 2023
Summary
Chronic rhinosinusitis (CRS) research is advancing through epigenetics, focusing on DNA methylation, histone modification, and microRNAs. Future epigenetic therapies show promise for treating this condition.
Area of Science:
- Otorhinolaryngology
- Genetics
- Molecular Biology
Background:
- Chronic rhinosinusitis (CRS) imposes a significant socioeconomic burden.
- The underlying mechanisms of CRS remain incompletely understood, potentially involving genetic and environmental factors.
- Epigenetic mechanisms are increasingly recognized as crucial in disease pathogenesis.
Purpose of the Study:
- To review recent advancements in epigenetic research related to chronic rhinosinusitis.
- To summarize findings concerning DNA methylation, histone modification, and non-coding RNA regulation in CRS.
- To highlight the potential of epigenetic therapies for CRS treatment.
Main Methods:
- Comprehensive literature review of epigenetic studies on chronic rhinosinusitis.
- Analysis of research focusing on DNA methylation patterns in CRS.
- Examination of studies investigating histone modifications and non-coding RNA (ncRNA) roles, particularly microRNAs (miRNAs), in CRS.
Main Results:
- Epigenetic research has significantly advanced the understanding of CRS mechanisms, especially in the last five years.
- MicroRNAs have emerged as a key area of epigenetic investigation in CRS.
- Studies reveal alterations in DNA methylation and histone modifications associated with CRS phenotypes.
Conclusions:
- Epigenetic dysregulation plays a critical role in the pathophysiology of chronic rhinosinusitis.
- The field of microRNA research in CRS has yielded substantial insights.
- Epigenetic modifications offer promising therapeutic targets, paving the way for novel "epigenetic therapies" for CRS.
Keywords:
DNA methylationchronic rhinosinusitiscircular RNAhistone modificationslong non-coding RNAmicroRNAnasal polypsMore Related Videos
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