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Natural biomolecules and derivatives as anticancer immunomodulatory agents
Stavroula Bernitsa1, Rotem Dayan1, Anastasis Stephanou1
1School of Medicine, European University Cyprus, Nicosia, Cyprus.
Natural phytochemicals show promise in cancer treatment by modulating the immune system. These plant-derived compounds can enhance cancer immunotherapy and chemotherapy effectiveness.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Chemotherapy resistance remains a significant challenge in cancer treatment.
- Cancer immunotherapy is a promising novel therapeutic strategy.
- Immunomodulation can enhance the efficacy of cancer treatments.
Purpose of the Study:
- To review plant-derived biomolecules as immunomodulators for cancer treatment.
- To explore the mechanisms of phytochemical-mediated immunomodulatory activity.
- To discuss the potential of phytochemicals in improving cancer immunotherapy and chemotherapy.
Main Methods:
- Literature review of natural phytochemicals with anticancer properties.
- Analysis of studies on phytochemicals' effects on tumor microenvironment and immune system.
- Examination of synergistic effects between phytochemicals and chemotherapeutics.
Main Results:
- Phytochemicals modulate both cancer pathways and immune responses.
- They remodel the tumor immunosuppressive microenvironment.
- Phytochemicals sensitize the immune system for better cancer cell targeting and synergize with chemotherapeutics.
Conclusions:
- Plant-derived phytochemicals possess immunomodulatory potential for cancer therapy.
- They offer a strategy to overcome chemotherapy resistance and enhance immunotherapy.
- Further research into these natural compounds could lead to novel cancer treatments.
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