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Updated: Aug 12, 2025

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

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Published on: November 23, 2017

Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression.

Seung-Hoon Lee¹, Cheolmin Shin², Young-Hoon Ko²

¹Department of Psychiatry, Veterans Health Service Medical Center, Seoul, Korea.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology

|January 26, 2023

Summary

Late-life depression is linked to lower plasminogen activator inhibitor-1 (PAI-1) levels, a chronic inflammation marker, especially when metabolic syndrome is considered. Geriatric depression may exhibit unique inflammatory patterns compared to younger populations.

Keywords:

Adipokine Depression Inflammation Metabolic syndrome Plasminogen activator inhibitor 1

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Published on: September 15, 2017

Area of Science:

Geriatric Psychiatry
Metabolic Syndrome Research
Inflammation Biomarkers

Background:

Late-life depression is associated with adipokines, markers of chronic inflammation.
Metabolic syndrome influences adipokine levels but its effect on geriatric depression and adipokines is understudied.

Purpose of the Study:

To investigate blood adipokine levels in geriatric depression.
To adjust for the impact of metabolic syndrome on these associations.

Main Methods:

Analyzed blood adipokine levels (adiponectin, resistin, NGAL, PAI-1) in geriatric depression patients (n=76) and controls (n=76).
Used multivariate logistic regression to adjust for metabolic syndrome and confounders.

Main Results:

Lower plasminogen activator inhibitor-1 (PAI-1) levels were observed in the geriatric depression group after adjusting for metabolic syndrome.
Adiponectin, resistin, and neutrophil-gelatinase-associated lipocalin (NGAL) did not significantly explain depression diagnosis.

Conclusions:

Blood PAI-1 levels may be a distinguishing factor in clinically pathological late-life depression.
Geriatric depression might present distinct inflammatory profiles compared to pre-geriatric populations.