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Related Concept Videos

Genomics02:02

Genomics

36.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.8K
Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Symbiosis00:58

Symbiosis

29.6K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
29.6K
Contact-dependent Signaling01:19

Contact-dependent Signaling

44.8K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

12.6K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Related Experiment Video

Updated: Aug 12, 2025

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

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The interactomics of academia.

Howy Jacobs1,2

  • 1Tampere University, Tampere, Finland.

EMBO Reports
|January 26, 2023
PubMed
Summary

Academic couples face reduced job prospects. This study explores challenges and solutions for dual-career scientist employment in academia.

Area of Science:

  • Academic careers
  • Sociology of science
  • Higher education employment

Background:

  • The academic job market presents unique challenges for couples where both partners are scientists.
  • Dual-career academic couples often face geographical constraints and limited opportunities, impacting career progression.

Purpose of the Study:

  • To investigate the specific difficulties encountered by scientist couples in securing satisfactory academic positions.
  • To identify potential strategies and institutional support mechanisms to help dual-career academic couples thrive.

Main Methods:

  • Qualitative analysis of career trajectories and job search experiences of dual-career academic couples.
  • Review of institutional policies and support systems for faculty recruitment and retention.

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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

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Related Experiment Videos

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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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Main Results:

  • Significant correlation between dual-career status and increased difficulty in obtaining tenure-track positions for both partners.
  • Limited availability of suitable positions within the same institution or geographical proximity.
  • Perceived lack of institutional support and proactive strategies for managing dual-career hires.

Conclusions:

  • Addressing the needs of dual-career academic couples requires targeted institutional policies and a more flexible approach to recruitment.
  • Strategies such as joint recruitment, spousal hiring assistance, and flexible work arrangements are crucial for retaining talent.
  • Facilitating the career fulfillment of both partners in a dual-career scientific couple is essential for maximizing scientific potential and productivity.