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Related Experiment Video

Updated: Aug 12, 2025

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

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Published on: January 18, 2018

Pod-based e-liquids impair human vascular endothelial cell function.

Sana Majid¹, Robert M Weisbrod¹, Jessica L Fetterman¹

¹Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, United States of America.

|January 26, 2023

Summary

This summary is machine-generated.

Pod-based e-cigarettes, containing nicotine salts, impair endothelial cell function, similar to traditional cigarettes. This suggests potential cardiovascular risks for users of these popular vaping devices.

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Area of Science:

Cardiovascular Science
Toxicology
Cell Biology

Background:

Pod-based electronic (e-) cigarettes deliver nicotine efficiently, but their cardiovascular effects remain unclear.
Endothelial cells are crucial for vascular health, and their dysfunction is linked to cardiovascular disease.

Purpose of the Study:

To evaluate the impact of pod-based e-liquids and their components on endothelial cell function.
To compare endothelial cell function in pod e-cigarette users with never users and combustible cigarette users.

Main Methods:

Endothelial cells were isolated from pod users, never users, and combustible cigarette users.
Human aortic endothelial cells (HAECs) were exposed to e-liquids, their components, and aerosols.
Acetylcholine-mediated endothelial nitric oxide synthase (eNOS) activation and nitric oxide production were measured.

Main Results:

Pod users showed reduced eNOS activation compared to never users, similar to combustible cigarette users.
E-liquids, propylene glycol:vegetable glycerol (PG:VG) vehicle, and nicotine salt induced cell death in HAECs.
Nitric oxide production was decreased by e-liquids, PG:VG, and nicotine salt; mint and menthol flavors induced inflammation and oxidative stress, respectively.

Conclusions:

Pod e-liquids and their constituents impair endothelial cell function.
These findings suggest potential cardiovascular harm associated with pod-based e-cigarette use.