Related Experiment Video
Updated: Aug 12, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
The Influence of Topical Perioperative Nepafenac on Retinal Vasculature Following Phacoemulsification Using Optical
Raghda Mahmoud Mohamed Ibrahim1, Safaa Galal Abdelkadous1, Tamer Ahmed Macky1
1The Department of Ophthalmology, Kasr El Aini Hospital, Cairo University, Cairo, Egypt.
Purpose:
To investigate topical nepafenac drops (TND) effect on retinal vasculature following uneventful phacoemulsification.
Methods:
54 eyes were randomly assigned to G1: TND 3 days preoperatively and 1 month postoperatively; G2: TND for 1 month postoperatively; and G3 no TND (control). BCVA, macular OCTA were compared baseline, 1 week and 1 month.
Results:
No statistically significant differences found between 3 groups in OCTA parameters during study visits. However, at 1 month (compared to baseline) there were a statistically significant increase in superficial capillary plexus (SCP) capillary vessel density (CVD) in G2 (p=0.036); increase in central foveal thickness (CFT) in G2 (p=0.011) and G3 (control) (p=0.001); and reduced number of patients with SCP disorganization in G2 (p=0.04). There were no significant correlation/association between most of OCTA parameters and final BCVA.
Conclusion:
TND use perioperative did not show any effect on retinal OCTA microvasculature and might affect macular edema by other mechanisms.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Glaucoma: Overview

