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Related Experiment Video

Updated: Aug 12, 2025

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
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An update on expanding HIV preexposure prophylaxis.

Jonathan Baker1, Joanne Rolls

  • 1Jonathan Baker is operation director of clinical research at Laser Surgery Care in New York, N.Y. Joanne Rolls is a clinical associate professor in the PA program at the University of Utah in Salt Lake City. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|January 26, 2023
PubMed
Summary

New guidelines recommend discussing HIV pre-exposure prophylaxis (PrEP) with all sexually active patients. This article explains how to optimize PrEP use, including new injectable options and telehealth, despite current underutilization.

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Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Medicine

Background:

  • HIV disproportionately affects sexual/gender minorities, racial/ethnic minorities, and underserved populations in the Southern US.
  • Recent CDC guidelines recommend discussing HIV pre-exposure prophylaxis (PrEP) with all sexually active patients.
  • The landscape of HIV prevention is evolving with new FDA-approved non-oral PrEP options and updated monitoring guidelines.

Purpose of the Study:

  • To describe optimal strategies for employing HIV pre-exposure prophylaxis (PrEP) in clinical practice.
  • To address recent significant changes in PrEP guidelines, including monitoring and telehealth.
  • To highlight the expanded use of PrEP with the introduction of long-acting injectable options.

Main Methods:

  • Review of updated CDC guidelines for HIV pre-exposure prophylaxis (PrEP).
  • Discussion of the implications of the FDA approval of long-acting injectable cabotegravir.
  • Analysis of changes in PrEP monitoring protocols and the integration of telehealth.

Main Results:

  • New CDC guidelines encourage broader discussion and consideration of PrEP for all sexually active patients.
  • Long-acting injectable cabotegravir offers a new non-oral PrEP option.
  • Updated guidelines address PrEP monitoring and telehealth, aiming to improve accessibility and adherence.

Conclusions:

  • Despite advancements and expanded recommendations, PrEP remains underused.
  • Optimizing PrEP implementation requires understanding and applying recent guideline changes and new therapeutic options.
  • Enhanced clinical strategies are needed to improve PrEP uptake and effectiveness in diverse populations.