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A nationwide survey of human metapneumovirus-associated encephalitis/encephalopathy in Japan

Ayumi Mori1, Yoshihiko Kawano1, Shinya Hara1

  • 1Department of Pediatrics, Toyota Memorial Hospital, Japan.

Brain & Development
|January 26, 2023
PubMed

Insights

Human metapneumovirus-associated encephalopathy (hMPVE) in children is rare, with outcomes similar to other viral encephalopathies. This study found no specific factors predicting poor outcomes in pediatric hMPVE cases.

Area of Science:

  • Pediatric neurology
  • Infectious diseases
  • Virology

Background:

  • Comprehensive reports on human metapneumovirus-associated encephalopathy (hMPVE) are lacking.
  • This study investigates the clinical features of hMPVE in Japanese children.

Purpose of the Study:

  • To examine the clinical features, treatment, and outcomes of hMPVE in children in Japan.
  • To identify potential factors associated with poor outcomes in pediatric hMPVE.

Main Methods:

  • A nationwide survey was conducted among Japanese pediatricians regarding children treated for hMPVE between 2014 and 2018.
  • Patient information was collected via surveys and literature searches, including demographics, symptoms, neurological findings, laboratory data, treatment, and outcomes using the Pediatric Cerebral Performance Category Score.

Main Results:

  • Clinical data from 16 children with hMPVE were analyzed; the median age was 37 months.
  • Outcomes were good in 11 patients and poor in 5, with no significant differences in demographic, neurological, or laboratory data between groups.
  • Encephalopathy subtypes included acute encephalopathy with biphasic seizures and late reduced diffusion, mild encephalitis/encephalopathy with a reversible splenial lesion, and hemorrhagic shock and encephalopathy syndrome.

Conclusions:

  • Outcomes in children with hMPVE were comparable to those associated with other viral encephalopathies.
  • No specific factors were identified that predicted poor outcomes in pediatric hMPVE cases.
Abstract

Keywords:
ChildrenEncephalopathyHuman metapneumovirusOutcome

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