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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Aug 12, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

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Systemic lupus erythematosus.

Yoshiya Tanaka1

  • 1The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

Best Practice & Research. Clinical Rheumatology
|January 26, 2023
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) treatments are evolving beyond traditional therapies. New targeted drugs, including belimumab and anifrolumab, offer hope for remission with fewer side effects.

Keywords:
Biological agentLupus nephritisSystemic lupus erythematosusTargeted therapyTreatment

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Area of Science:

  • Immunology
  • Rheumatology
  • Pharmacology

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease causing multi-organ damage.
  • Current treatments, primarily glucocorticoids and immunosuppressants, lack specificity and have adverse effects.
  • The goal of SLE treatment is achieving remission without systemic symptoms or organ damage.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for Systemic Lupus Erythematosus.
  • To highlight the shift towards targeted therapies with improved safety profiles.
  • To discuss novel drug development focusing on specific immune pathways in SLE.

Main Methods:

  • Review of existing literature on SLE pathogenesis and treatment.
  • Analysis of recently approved and investigational drugs for SLE.
  • Focus on molecular targets within immune cell signaling pathways.

Main Results:

  • Belimumab (anti-B-cell activating factor) and anifrolumab (anti-type I interferon receptor) are approved for active SLE.
  • Emerging therapies target key immune cells and signaling molecules like Janus kinase inhibitors and proteasome inhibitors.
  • Susceptibility genes in SLE highlight the importance of dendritic and B cell signaling.

Conclusions:

  • Targeted therapies represent a significant advancement in SLE management.
  • Future SLE treatments aim for greater efficacy and reduced toxicity by targeting specific immune mechanisms.
  • Continued research into SLE pathogenesis is crucial for developing next-generation therapies.