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Related Experiment Video

Updated: Aug 12, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Core-Shell Type Lipidic and Polymeric Nanocapsules: the Transformative Multifaceted Delivery Systems.

Arti Mehandole¹, Nikita Walke¹, Srushti Mahajan¹

¹Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, Telangana, India.

AAPS Pharmscitech

|January 26, 2023

Summary

This summary is machine-generated.

Lipid or polymer-based core-shell nanocapsules (NCs) offer advanced drug delivery. These systems enhance bioavailability and enable targeted delivery via various administration routes.

Keywords:

core–shell lipid nanocapsules nanoparticles polymer targeting

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Area of Science:

Nanotechnology
Materials Science
Pharmaceutical Sciences

Background:

Core-shell nanocapsules (NCs) are versatile nano-drug delivery systems.
They consist of a core (aqueous/oily) and a lipidic or polymeric shell.
Biocompatible materials and surface modifications make NCs ideal for drug delivery.

Purpose of the Study:

To review fabrication methods and characterization of lipidic and polymeric NCs (LNCs and PNCs).
To demonstrate applications in oral, parenteral, nasal, and transdermal drug delivery.
To provide insights into NC absorption, surface modification, size tuning, and toxicity.

Main Methods:

Review of existing literature on lipidic and polymeric nanocapsule systems.
Emphasis on fabrication techniques and characterization methodologies.
Analysis of application data across various administration routes.

Main Results:

NCs enhance bioavailability for challenging-to-formulate drugs.
Sustained and targeted drug delivery is achievable.
NCs offer improved absorption mechanisms, tunable sizes, and moderated toxicity.

Conclusions:

Core-shell nanocapsules represent a significant advancement over conventional drug delivery methods.
NCs show great potential for diverse pharmaceutical applications.
Future research should address current challenges and explore novel applications.