Optimization of Process and Formulation Variables for Semha-Pinas Extract Effervescent Tablets Using the Box-Behnken...

Area of Science:

• Pharmaceutical Technology
• Herbal Medicine Formulation
• Process Optimization

Background:

• Semha-Pinas (SHPN) is a Thai traditional herbal formula traditionally administered as pills.
• The traditional pill form requires dispersion in water, presenting an opportunity for dosage form innovation.
• Effervescent tablets offer enhanced patient convenience and potentially faster drug release.

Purpose of the Study:

• To develop and optimize Semha-Pinas (SHPN) extract effervescent tablets.
• To improve patient convenience and reduce disintegration time compared to traditional dosage forms.
• To identify optimal formulation and process parameters for SHPN effervescent tablets.

Main Methods:

• Utilized Box-Behnken design for formulation and process optimization.
• Screened independent variables: compressional force, effervescent base quantity, and fumed silica quantity.
• Monitored responses: tablet thickness, hardness, disintegration time, and friability.

Main Results:

• Optimal parameters identified: 2000 psi compressional force, 50% effervescent base, 2.5% fumed silica.
• Achieved desired tablet properties: hardness > 5 kP, disintegration time < 5 min, friability < 1%.
• Optimized formulation exhibited hardness of 5.57 kP, disintegration time of 1.68 min, and friability of 0.43%.

Conclusions:

• Successfully developed Semha-Pinas (SHPN) extract effervescent tablets with desirable characteristics.
• The effervescent tablet formulation enhances ease of use and reduces disintegration time.
• This optimized dosage form represents a significant improvement over the traditional SHPN pill formulation.