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Design, synthesis and applications of responsive macrocycles
Jingjing Yu1, Dawei Qi1, Jianwei Li2,3
1MediCity Research Laboratory, University of Turku, Tykistökatu 6, 20520, Turku, Finland.
Communications Chemistry
|January 27, 2023
Summary
Responsive macrocycles (RMs) are dynamic molecules inspired by host-guest chemistry. This review explores their design, synthesis, and applications for creating functional materials with controlled properties.
Area of Science:
- Supramolecular Chemistry
- Host-Guest Chemistry
- Materials Science
Background:
- The field of supramolecular chemistry has advanced significantly, driven by the lock and key principle in host-guest interactions.
- Emerging research in responsive macrocycles (RMs) is building upon established models like induced-fit and conformation selection.
Purpose of the Study:
- To introduce responsive macrocycles (RMs), detailing their fundamental design principles.
- To cover the synthetic methodologies employed for creating RMs.
- To explore the diverse applications of RMs in developing functional materials.
Main Methods:
- Review of existing literature on macrocyclic chemistry and host-guest systems.
- Analysis of design strategies for responsive macrocycles.
- Compilation of synthetic routes for RMs.
- Survey of current and potential applications of RMs.
Main Results:
- Responsive macrocycles offer dynamic control over molecular behavior.
- The design and synthesis of RMs enable the creation of materials with tunable functions.
- RMs represent a promising area for advanced materials development.
Conclusions:
- Responsive macrocycles are key to advancing host-guest chemistry and supramolecular design.
- Understanding RM dynamics facilitates the development of smart materials.
- This review provides a comprehensive overview for researchers in the field.
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