Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
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Updated: Aug 12, 2025

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
Yue Weng1, Chunlan Song2, Chien-Wei Chiang3
1Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecule & School of Chemistry and Chemical Engineering, Hubei University, 430062, Wuhan, Hubei, China.
Abstract:
Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developments in visible-light induced photoredox catalysis and electrochemical catalysis reactions have permitted significant novel reactivities to be developed in the field of synthetic and bioconjugation chemistry. This perspective describes recent advances in the use of biocompatible energy input for the modification of peptides and proteins mainly, via the single electron transfer (SET) process, as well as key future developments in this area.
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