Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input.

Area of Science:

• Synthetic Chemistry
• Bioconjugation Chemistry
• Catalysis

Background:

• Bioconjugation is crucial for modifying peptides and proteins.
• Early methods faced limitations in substrate scope and reagent biocompatibility.
• Recent catalysis advancements offer new possibilities.

Purpose of the Study:

• To review recent progress in biocompatible energy inputs for peptide and protein modification.
• To highlight the role of single electron transfer (SET) in these reactions.
• To discuss future directions in the field.

Main Methods:

• Focus on visible-light photoredox catalysis.
• Emphasis on electrochemical catalysis.
• Discussion of single electron transfer (SET) mechanisms.

Main Results:

• Novel reactivities have been developed using visible-light and electrochemical catalysis.
• Biocompatible energy inputs enable efficient bioconjugation.
• The SET process is central to these new methods.

Conclusions:

• Biocompatible energy inputs represent a significant advancement in bioconjugation.
• These methods overcome previous limitations in substrate scope and biocompatibility.
• Future developments promise further innovation in modifying peptides and proteins.