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ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden

Gerrit M Grosse1, Andrei Leotescu1, Jan-Thorben Sieweke2

  • 1Department of Neurology, Hannover Medical School, Hannover, Germany.

Frontiers in Neurology
|January 27, 2023
PubMed

Insights

A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS-13) activity is lower in patients with more vascular risk factors for stroke. This suggests ADAMTS-13 may play a role in cerebrovascular risk.

Area of Science:

  • Neurology
  • Vascular Biology
  • Biochemistry

Background:

  • Understanding ischemic stroke mechanisms is crucial for secondary prevention strategies.
  • A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS-13) possesses antithrombotic properties and is implicated in stroke pathophysiology.
  • The association between ADAMTS-13 and stroke etiology, along with vascular risk factors, requires further investigation.

Purpose of the Study:

  • To investigate the association between ADAMTS-13 activity and stroke etiology.
  • To explore the relationship between ADAMTS-13 activity and the burden of vascular risk factors in stroke patients.

Main Methods:

  • ADAMTS-13 activity was measured in two prospectively recruited stroke cohorts.
  • Cohort 1 included patients with stroke due to ESUS, AF, large-artery atherosclerosis, or small vessel disease (n=88).
  • Cohort 2 comprised patients with cryptogenic stroke and PFO undergoing PFO closure (n=38).
  • Vascular risk factor burden was assessed using CHA2DS2VASC, ESRS, and RoPE scores.

Main Results:

  • ADAMTS-13 activity was lower in AF-related stroke patients compared to ESUS patients, though this was confounded by vascular risk factors.
  • ADAMTS-13 activity showed an inverse correlation with ESRS (r=-0.452, p<0.001) and CHA2DS2VASC (r=-0.375, p<0.001) in cohort 1.
  • A positive correlation was observed between ADAMTS-13 activity and the RoPE score in cohort 2 (r=0.413, p=0.010).

Conclusions:

  • ADAMTS-13 activity is inversely correlated with the number of vascular risk factors across various stroke etiologies.
  • These findings suggest a potential role for ADAMTS-13 in mediating cerebrovascular risk.
  • Further research is warranted to elucidate the precise role of ADAMTS-13 in stroke pathophysiology and prevention.
Abstract

Keywords:
ADAMTS-13biomarkerembolic stroke of undetermined sourcepatent foramen ovalestroke etiologythrombosis

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