Related Experiment Video
Updated: Aug 12, 2025
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.4K
Advances in immunotherapy modalities for atherosclerosis.
Qingwen Meng1,2,3, Huajiang Liu2, Jinteng Liu4
1Department of Pharmacy, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Frontiers in Pharmacology
|January 27, 2023
Summary
Atherosclerosis, the basis of cardiovascular disease, is an immune-mediated inflammatory condition. Immunotherapy shows promise for preventing and treating atherosclerosis by modulating immune responses.
Area of Science:
- Immunology
- Cardiovascular Science
- Inflammation Research
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- Atherosclerosis, the foundation of atherosclerotic cardiovascular disease (ASCVD), is a chronic immune-mediated inflammatory process.
- Key factors include endothelial dysfunction, lipid accumulation, and immune cell infiltration (macrophages).
Purpose of the Study:
- To review recent advancements in understanding the immune mechanisms underlying atherosclerosis.
- To explore targeted immunotherapy pathways for atherosclerosis prevention and treatment.
Main Methods:
- Literature review of recent studies on immune mechanisms in atherosclerosis.
- Analysis of clinical trial data associating immune cells and factors with atherosclerosis.
- Synthesis of research on antigen-induced immune responses for atherosclerosis modulation.
Main Results:
- Atherosclerosis involves both innate and adaptive immunity.
- Inducing protective immune responses via auto-antigens or exogenous antigens can alleviate atherosclerosis.
- Immune cells and factors are significantly associated with atherosclerotic conditions.
Conclusions:
- Immunotherapy presents a novel and promising strategy for preventing and treating atherosclerosis.
- Targeting immune pathways offers a new therapeutic avenue for ASCVD.
Related Concept Videos
01:26Atherosclerosis III: Management
16
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
01:27Tumor Immunotherapy
617
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
617
01:23Atherosclerosis IV: Nursing Management
35
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
35
01:30Atherosclerosis I: Introduction
32
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
32
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
26
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
26
01:30Cancer Vaccines
474
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
474