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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment
Qian Wei1, Xi Liu1, Jian-Long Su1
1Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and the 4th Medical Center of Chinese, PLA General Hospital, Beijing, China.
Abstract:
Chronic non-healing wounds have posed a severe threat to patients mentally and physically. Behavior dysregulation of remaining cells at wound sites is recognized as the chief culprit to destroy healing process and hinders wound healing. Therefore, regulating and restoring normal cellular behavior is the core of chronic non-healing wound treatment. In recent years, the therapy with mesenchymal stem cells (MSCs) has become a promising option for chronic wound healing and the efficacy has increasingly been attributed to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) are reported to benefit almost all stages of wound healing by regulating the cellular behavior to participate in the process of inflammatory response, angiogenesis, re-epithelization, and scarless healing. Here, we describe the characteristics of MSC-sEVs and discuss their therapeutic potential in chronic wound treatment. Additionally, we also provide an overview of the application avenues of MSC-sEVs in wound treatment. Finally, we summarize strategies for large-scale production and engineering of MSC-sEVs. This review may possibly provide meaningful guidance for chronic wound treatment with MSC-sEVs.
Insights
Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) show promise for treating chronic wounds by regulating cellular behavior. This review explores their therapeutic potential and production strategies for wound healing.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Wound Healing Research
Background:
- Chronic non-healing wounds significantly impair patient well-being.
- Dysregulated cellular behavior at wound sites is a primary barrier to healing.
- Mesenchymal stem cells (MSCs) offer therapeutic potential, largely via exocrine functions.
Purpose of the Study:
- To review the characteristics of MSC-derived small extracellular vesicles (MSC-sEVs).
- To discuss the therapeutic potential of MSC-sEVs in chronic wound treatment.
- To explore application avenues and production strategies for MSC-sEVs in wound care.
Main Methods:
- Review of existing literature on MSC-sEVs and their role in wound healing.
- Analysis of MSC-sEV characteristics and mechanisms of action.
- Discussion of current and future applications in chronic wound management.
Main Results:
- MSC-sEVs positively influence inflammatory response, angiogenesis, and re-epithelialization.
- These vesicles promote scarless healing by modulating cellular behavior.
- MSC-sEVs represent a promising cell-free therapeutic strategy for chronic wounds.
Conclusions:
- MSC-sEVs are a viable therapeutic option for chronic non-healing wounds.
- Further research into large-scale production and engineering is warranted.
- This review provides guidance for utilizing MSC-sEVs in clinical wound treatment.
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