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Post-COVID Multisystem Inflammatory Syndrome-Adult (MIS-A) Presenting with Rhabdomyolysis and AKI

Mastakim Ahmed Mazumder1, Ajit Singh Narula2, Sanjeev Gulati2

  • 1Consultant Nephrology and Kidney Transplant, Kidney and Urology Institute, Fortis Escorts, Okhla, New Delhi, India.

Indian Journal of Nephrology
|January 27, 2023
PubMed

Insights

Multisystem inflammatory syndrome in adults (MIS-A) is a rare post-COVID condition. This case highlights rhabdomyolysis as an unusual MIS-A presentation, emphasizing prompt diagnosis and treatment for recovery.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Neurology

Background:

  • Multisystem inflammatory syndrome in adults (MIS-A) is a rare post-coronavirus disease (COVID-19) complication.
  • Clinical presentations and treatment strategies for MIS-A are diverse, primarily documented through case reports.
  • Rhabdomyolysis is an uncommon manifestation of MIS-A.

Observation:

  • A 61-year-old male presented with rhabdomyolysis and acute kidney injury (AKI).
  • Additional symptoms included acute inflammatory demyelinating polyneuropathy (AIDP), myocarditis, and disseminated intravascular coagulation.
  • The patient exhibited minimal respiratory symptoms, suggesting a non-typical COVID-19 presentation.

Findings:

  • The patient was diagnosed with post-COVID inflammatory syndrome (MIS-A).
  • Diagnosis was supported by positive COVID-19 antibody testing.
  • Treatment involved supportive care and intravenous immunoglobulin (2 g/kg over 5 days).

Implications:

  • This case expands the understanding of MIS-A presentations, including severe rhabdomyolysis.
  • Early diagnosis of MIS-A, aided by serological testing, is crucial for timely intervention.
  • Effective management can lead to favorable outcomes in patients with complex MIS-A manifestations.
Keywords:
Acute kidney injuryCOVID-19multisystem inflammatory syndrome–adultrhabdomyolysis

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