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Efficacy of a home-used high-intensity focused ultrasound device on wrinkle reduction
Mi Hee Kwack1,2, Weon Ju Lee3
1Department of Immunology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Background:
High-intensity focused ultrasound (HIFU) has been developed for the treatment of skin wrinkles on the face, neck, and body.
Objectives:
This study aimed to evaluate the effects of a home-used HIFU device on wrinkles in mice based on the expression of fibrosis-related genes and proteins.
Methods:
The backs of 20-week-old mice were treated with a home-used HIFU using the following probes: 4 MHz, 1.5 mm focal depth. The treated mice were compared with young mice by histological examination, real-time polymerase chain reaction (PCR), and immunohistochemistry. Histological examination was performed by trichrome staining. Real-time PCR and immunohistochemistry were conducted to determine the expression of collagen types I and III, matrix metalloproteinase (MMP)-1, and tissue inhibitor of metalloproteinase (TIMP)-1.
Results:
Dermal thickness was increased after treatment with the home-used HIFU device at 30 and 60 s per day for 1 week or 30 and 60 s per day for 2 weeks on trichrome. Gene and protein expression of collagen types I and III and elastin were increased after treatment with HIFU at all options of 30 and 60 s per day for 1 week or 30 and 60 s per day for 2 weeks. Gene and protein expressions of MMP-1 and TIMP-1 were decreased after treatment with HIFU device at 30 and 60 s per day for 1 week or 30 and 60 s per day for 2 weeks.
Conclusion:
The home-used HIFU device can be an effective therapeutic modality for skin tightening.
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