Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

178
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
178
Behavior Therapy01:22

Behavior Therapy

95
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
95
Anxiety: Overview01:18

Anxiety: Overview

326
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
326
Anxiolytic Drugs: Overview01:26

Anxiolytic Drugs: Overview

410
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
410
Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

1.0K
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
1.0K
Social Anxiety Disorder01:28

Social Anxiety Disorder

70
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
70

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ageing and anxiety: Prevalence of anxiety in older adults with psychotic illnesses.

The Australian and New Zealand journal of psychiatryยท2025
Same author

Profiling people with Parkinson's disease at risk of cognitive decline: Insights from PPMI and ICICLE-PD data.

Alzheimer's & dementia (Amsterdam, Netherlands)ยท2024
Same author

Patient outcome quality indicators for older persons in acute care: original development data using interRAI AC-CGA.

BMC geriatricsยท2024
Same author

Telehealth Cognitive Behavior Therapy to Reduce Anxiety in People Living with Cognitive Impairment: A Randomized Feasibility Pilot Study.

Clinical gerontologistยท2024
Same author

Hippocampal resting-state connectivity is associated with posterior-cortical cognitive impairment in Parkinson's disease.

Brain and behaviorยท2024
Same author

Predictors of the placebo response in a nutraceutical randomized controlled trial for depression.

Journal of integrative medicineยท2024

Related Experiment Video

Updated: Aug 12, 2025

The use of Biofeedback in Clinical Virtual Reality: The INTREPID Project
06:52

The use of Biofeedback in Clinical Virtual Reality: The INTREPID Project

Published on: November 12, 2009

15.3K

Interventions for generalized anxiety disorder.

Gerard J Byrne1,2

  • 1Academy of Psychiatry, School of Medicine, University of Queensland.

Current Opinion in Psychiatry
|January 27, 2023
PubMed
Summary

Generalized anxiety disorder (GAD) treatments include antidepressants and quetiapine. Emerging evidence supports physical exercise and internet-based cognitive behavioral therapy (CBT) for GAD management.

More Related Videos

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

7.6K
Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

15.3K

Related Experiment Videos

Last Updated: Aug 12, 2025

The use of Biofeedback in Clinical Virtual Reality: The INTREPID Project
06:52

The use of Biofeedback in Clinical Virtual Reality: The INTREPID Project

Published on: November 12, 2009

15.3K
Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

7.6K
Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

15.3K

Area of Science:

  • Psychiatry and Psychology
  • Neuroscience

Background:

  • Generalized anxiety disorder (GAD) prevalence increased during the COVID-19 pandemic.
  • Current treatment landscape for GAD involves pharmacotherapy and psychotherapy, with ongoing debates regarding the efficacy of different modalities.

Approach:

  • Systematic review of recent literature on GAD and its treatments.
  • Analysis of drug efficacy, psychological interventions, and complementary therapies.

Key Points:

  • Selective serotonin reuptake inhibitors (SSRIs), agomelatine, and quetiapine demonstrate efficacy for GAD.
  • Internet-based cognitive behavioral therapy (CBT) is a viable alternative for GAD treatment when in-person therapy is inaccessible.
  • Physical exercise, yoga, acupuncture, and Withania somnifera show some evidence of efficacy.
  • Cannabinoids lack sufficient evidence for anxiety disorder treatment.

Conclusions:

  • Antidepressants and quetiapine are effective pharmacological treatments for GAD.
  • Internet-based CBT and physical exercise are increasingly recognized as valuable components in GAD management.
  • Further rigorous research is needed for complementary therapies, including cannabinoids.