Related Experiment Video
Updated: Aug 12, 2025
09:42
Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
Published on: April 19, 2017
7.5K
Epigenetic control of skin immunity
1Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Immunological Medicine
|January 27, 2023
Summary
Epigenetic mechanisms like histone modification regulate skin immunity. Understanding these processes is key to addressing chronic skin immune disorders.
Area of Science:
- Immunology
- Epigenetics
- Dermatology
Background:
- Epigenetics traditionally studied in cell development, now recognized for immune cell activation.
- Skin homeostasis relies on immune and non-immune cell communication.
- Epigenetic dysregulation can disrupt skin immune balance.
Purpose of the Study:
- To review epigenetic regulation of skin immunity.
- Focus on histone modification and chromatin remodeling roles.
- Explore links to immune-regulatory factor transcription.
Main Methods:
- Literature review of recent evidence.
- Focus on DNA methylation, histone modification, and chromatin remodeling.
- Analysis of transcriptional regulation in skin immunity.
Main Results:
- DNA methylation is a known epigenetic factor in skin immunity.
- Histone modification and chromatin remodeling are increasingly recognized.
- These epigenetic processes influence immune-regulatory factors in the skin.
Conclusions:
- Epigenetic regulation, particularly histone modification and chromatin remodeling, is crucial for skin immunity.
- Dysregulation may contribute to chronic cutaneous immune disorders.
- Further research is needed to fully elucidate these mechanisms.
Related Concept Videos
01:12Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
01:19Pigmentation
2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
01:46Epigenetic Regulation
31.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.2K
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:23Skin Diseases and Disorders
4.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.0K
01:24Cells of the Epidermis
4.1K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
4.1K