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Follow up of renal outcomes in children with solitary kidney

Esra Nagehan Akyol Onder1, Omer Yilmaz2, Can Taneli3

  • 1Department of Pediatric Nephrology, Manisa Celal Bayar University, School of Medicine, Manisa, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|January 27, 2023
PubMed

Insights

Children with solitary kidney (SK) face risks of renal injury, particularly those with acquired SK (ASK). Controlling uric acid levels is crucial for preventing kidney damage in these patients.

Area of Science:

  • Pediatric Nephrology
  • Renal Outcomes
  • Urology

Background:

  • Solitary kidney (SK) affects 1 in 1000 individuals globally.
  • Renal outcomes in patients with SK remain debated.
  • This study addresses clinical findings and renal outcomes in pediatric SK patients.

Purpose of the Study:

  • Investigate clinical findings and renal outcomes in children with solitary kidney (SK).
  • Compare outcomes between congenital solitary kidney (CSK) and acquired solitary kidney (ASK) groups.

Main Methods:

  • Retrospective analysis of demographic and clinical data.
  • Inclusion of pediatric patients with SK from January 2010 to January 2021.
  • Comparison between CSK and ASK patient cohorts.

Main Results:

  • 101 pediatric patients with SK were analyzed (71 CSK, 30 ASK).
  • ASK patients exhibited significantly higher serum uric acid and lower estimated glomerular filtration rate compared to CSK patients.
  • A positive correlation was found between renal injury and serum uric acid levels (r=0.45).

Conclusions:

  • Patients with acquired solitary kidney (ASK) face a higher risk of renal injury than those with congenital solitary kidney (CSK).
  • Uric acid level control is vital for preventing renal injury in SK patients, especially in the ASK group.
  • Development of novel biomarkers for early renal damage detection in SK is needed.
Abstract

Keywords:
multicystic dysplastic kidneynephrectomysolitary functioning kidneysolitary kidneyunilateral renal agenesis

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