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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

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Updated total IgE reference intervals in Norwegian adults.

Erik Wilhelm Vinnes¹, Birthe Skarbø¹, Tore Wentzel-Larsen^2,3,4

¹Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.

Immunity, Inflammation and Disease

|January 27, 2023

Summary

New reference intervals for total immunoglobulin E (IgE) in healthy Norwegian adults were established. Current widely used intervals are outdated, showing significantly lower values than this study

Keywords:

immunoglobulin E in vitro allergy testing reference intervals reference range reference values total IgE

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Area of Science:

Clinical immunology
Laboratory medicine

Background:

Laboratories must provide clinicians with updated reference intervals.
Recent data on adult total IgE reference intervals for Scandinavian populations are scarce.
This study aimed to estimate reference intervals for healthy Norwegian adults.

Purpose of the Study:

To establish updated reference intervals for total immunoglobulin E (IgE) in a healthy Norwegian adult population.
To address the lack of recent data on IgE levels in this demographic.
To provide a basis for critical review and updating of current clinical laboratory practices.

Main Methods:

A reference interval study was conducted following CLSI guidelines.
Samples were collected from 252 presumably healthy adult participants from a regional blood donation program.
Total IgE was measured using the ImmunoCAP platform, traceable to the WHO-reference standard.

Main Results:

The upper 95% total IgE reference limit was estimated at 302 kU/L (90% CI: 177-388 kU/L).
The 97.5th percentile was estimated at 391 kU/L (90% CI: 344-560 kU/L).
No significant difference in total IgE levels was observed between participants with and without self-reported allergic diseases.

Conclusions:

Current adult total IgE reference intervals, established decades ago, are likely outdated.
This study's findings suggest significantly higher total IgE values in healthy Norwegian adults compared to historical intervals.
Clinical laboratories should critically review and update their total IgE reference intervals based on current population data.