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Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Atchariya Chanpong1,2,3, Nikhil Thapar2,3,4,5

  • 1From the Division of Gastroenterology and Hepatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Journal of Pediatric Gastroenterology and Nutrition
|January 27, 2023
PubMed

Insights

Pediatric neurogastroenterology and motility disorders are common and severe in children, often poorly understood and treated. Emerging research focuses on early life factors and novel therapies like bioelectrical neuromodulation for better outcomes.

Area of Science:

  • Pediatric Gastroenterology
  • Neurogastroenterology and Motility
  • Gastrointestinal (GI) Disorders in Children

Background:

  • GI motility disorders in children are prevalent, severe, yet poorly understood, diagnosed, and treated.
  • The field has seen slow progress but is poised for significant advancements.
  • Understanding the etiopathogenesis of these disorders is critical.

Approach:

  • Reviewing recent and futuristic developments in investigative and diagnostic tools.
  • Highlighting novel management approaches for pediatric GI motility disorders.
  • Focusing on emerging areas like early life programming and insult of the enteric neuromusculature.

Key Points:

  • Early life programming and insults to the enteric neuromusculature are key determinants of motility diseases.
  • Advancements in diagnostic tools are improving the understanding and identification of these disorders.
  • Personalized medicine, including pharmacological and multidisciplinary strategies, is transforming treatment.

Conclusions:

  • The future of pediatric neurogastroenterology and motility is promising, with a focus on understanding disease origins.
  • Novel therapeutic options like bioelectrical neuromodulation and regenerative medicine offer new hope.
  • Targeted and personalized approaches are essential for effective management of pediatric GI motility disorders.

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