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Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present

Hayder M Al-Kuraishy1, Ali I Al-Gareeb1, Helal F Hetta2

  • 1Department of Clinical Pharmacology and Therapeutic Medicine, College of Medicine, ALmustansiriyiah University, Baghdad, Iraq.

AMB Express
|January 27, 2023
PubMed

Insights

Heparanase (HPSE) plays a key role in severe inflammation and blood clotting during SARS-CoV-2 and monkeypox virus infections. Inhibiting HPSE may reduce disease severity and complications in co-infected patients.

Area of Science:

  • Biochemistry
  • Virology
  • Immunology

Background:

  • Heparanase (HPSE) is an enzyme that degrades heparan sulfate (HS) in the extracellular matrix.
  • HPSE activity is linked to inflammation, cytokine storm, and coagulopathy.
  • Both SARS-CoV-2 and monkeypox virus (MPXV) induce HPSE expression.

Purpose of the Study:

  • To investigate the role of HPSE in SARS-CoV-2 and MPXV infections.
  • To explore HPSE as a potential therapeutic target for viral co-infections.

Main Methods:

  • The study focuses on the molecular interactions and biological consequences of HPSE activity.
  • Analysis of HPSE induction by SARS-CoV-2 and MPXV.
  • Discussion of potential therapeutic strategies targeting HPSE.

Main Results:

  • HPSE cleavage of HS activates autophagy and releases growth factors.
  • HPSE triggers pro-inflammatory cytokine release, leading to hyperinflammation and cytokine storm.
  • HPSE contributes to endothelial dysfunction and thrombotic events in viral infections.

Conclusions:

  • HPSE is implicated in the pathogenesis of both SARS-CoV-2 and MPXV infections.
  • Co-infection with SARS-CoV-2 and MPXV may exacerbate HPSE-mediated complications.
  • Targeting HPSE with inhibitors could mitigate severe outcomes in these viral infections.
Keywords:
HeparanaseMonkeypoxSARS-CoV-2

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