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Alzheimer Disease l: Introduction

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Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

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A Novel Digital Digit-Symbol Substitution Test Measuring Processing Speed in Adults At Risk for Alzheimer Disease:

Anthony Campitelli¹, Sally Paulson¹, Josh L Gills¹

¹Exercise Science Research Center, University of Arkansas, Fayetteville, AR, United States.

|January 27, 2023

Summary

This study validates a new digital processing speed assessment (DDSST) against a gold standard. Results show the DDSST is a valid and suitable tool for widespread cognitive screening.

Keywords:

Alzheimer disease aging cognitive dementia digit-symbol substitution processing speed

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Area of Science:

Neuroscience
Cognitive Psychology
Digital Health

Background:

Alzheimer disease detection relies on assessing cognitive functions like processing speed (PS).
Digital PS assessments offer accessible testing but require robust validation beyond simple correlation.
Best practices for concurrent validity emphasize agreement and equivalence measures.

Purpose of the Study:

To evaluate the concurrent validity of a novel digital processing speed assessment (DDSST).
To compare the DDSST against a gold-standard measure, the Repeatable Battery for the Assessment of Neuropsychological Status coding test (RBANS-C).

Main Methods:

191 adults aged 45-75 completed both the DDSST and RBANS-C.
Concurrent validity was assessed using Pearson correlation, dependent t-tests, Bland-Altman limits of agreement, and two one-sided t-tests (TOST).

Main Results:

A significant moderate positive correlation (r=.577) was observed between DDSST and RBANS-C scores.
No significant difference in mean scores was found between the two tests (P=.93).
The DDSST demonstrated adequate agreement and statistical equivalence to the RBANS-C (P=.049).

Conclusions:

The digital digit-symbol substitution test (DDSST) is a valid measure of processing speed.
The DDSST is a suitable tool for efficient and widespread processing speed testing.