Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neurotensin in the human brain.

J K Mai¹, J Triepel, J Metz

¹C. & O. Vogt-Institut für Hirnforschung und Anatomie I, Universität Düsseldorf, F.R.G.

|August 1, 1987

Summary

Neurotensin is widely distributed in the adult human brain, particularly in the hypothalamus and limbic system. This peptide is also found in pathways related to catecholaminergic neurons.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of cholesterol re-supplementation and atorvastatin on plaque composition in the thoracic aorta of New Zealand white rabbits.

BMC cardiovascular disorders·2020

Same author

A Simple Innovative Technique for Managing Large Cystic Benign Adnexal Masses Using Single Port Laparoscopic Surgery.

Journal of minimally invasive gynecology·2016

Same author

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia.

Molecular psychiatry·2014

Same author

Predicting Outcomes in Locally-Advanced Rectal Cancer Using Pretreatment FDG-PET Imaging.

Practical radiation oncology·2014

Same author

Turnover of the D1 protein and of Photosystem II in a Synechocystis 6803 mutant lacking Tyrz.

Photosynthesis research·2013

Same author

Reply from m. Heino, j.a.j. Metz and v. Kaitala.

Trends in ecology & evolution·2011

Area of Science:

Neuroscience
Immunocytochemistry
Neuroanatomy

Background:

Neurotensin is a neuropeptide with a poorly understood distribution in the adult human brain.
Previous studies in rodents suggest a broad neurotensin presence, but human data is limited.

Purpose of the Study:

To map the precise localization of neurotensin-immunoreactive sites in the adult human central nervous system.
To compare the distribution of neurotensin in humans with findings in rodents.

Main Methods:

Indirect immunoperoxidase method (Sternberger, 1979) was employed.
Neurotensin antiserum was used to identify immunoreactive cells and processes.
Mapping studies were conducted on sections of the adult human brain.

Main Results:

Neurotensin-immunoreactive cells and fibers are widespread but unevenly distributed throughout the human brain.
Prominent cell populations were identified in the medial hypothalamus and limbic system (amygdala, septum, piriform cortex).
Neurotensin fibers were abundant in hypothalamic, limbic, thalamic, brainstem, and vagus-solitarius regions, often co-localizing with catecholaminergic cell clusters.

Conclusions:

The study provides a comprehensive map of neurotensin distribution in the adult human brain.
Findings suggest a significant role for neurotensin in various brain functions, including those involving the limbic system and catecholaminergic pathways.
The human neurotensin distribution pattern shows similarities to that observed in rodents.

Related Experiment Videos