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Does Bupropion Increase Anxiety?: A Naturalistic Study Over 12 Weeks.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Psychology

Background:

  • Clinical observations suggest bupropion may increase anxiety.
  • Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for anxiety disorders.

Purpose of the Study:

  • To compare anxiety severity over time between patients prescribed SSRIs and those prescribed bupropion.
  • To investigate the clinical belief that bupropion exacerbates anxiety.

Main Methods:

  • Retrospective analysis of 8457 patients from tele-mental health records.
  • Propensity matching used to create comparable SSRI and bupropion groups based on 17 covariates.
  • Repeated measures ANOVA on Generalized Anxiety Disorder Scale 7 (GAD-7) scores at baseline, 6 weeks, and 12 weeks.

Main Results:

  • In the overall sample, bupropion group showed higher initial anxiety levels.
  • After propensity matching, no significant difference in anxiety levels between SSRI and bupropion groups was observed.
  • Both groups demonstrated comparable improvement in anxiety symptoms over the 12-week treatment period.

Conclusions:

  • Propensity matching indicates no significant difference in anxiety outcomes between SSRI and bupropion treatments over 12 weeks.
  • The study challenges the clinical belief that bupropion inherently exacerbates anxiety when compared to SSRIs.