Hierarchical copper-based metal-organic frameworks nanosheet assemblies for electrochemical ascorbic acid sensing.

Area of Science:

• Electrochemistry
• Materials Science
• Nanotechnology

Background:

• Noninvasive human health monitoring necessitates sensitive electrochemical sensors for trace biomolecule detection.
• Ascorbic acid (AA) is a crucial biomolecule for human health, requiring accurate quantification.

Purpose of the Study:

• To develop a novel hierarchical nanosheet assemblies (HSA) of copper-based metal-organic frameworks (MOFs) as an efficient electrochemical sensor for ascorbic acid (AA) detection.
• To investigate the performance of the CuBDC HSA-based sensor for AA detection in various samples.

Main Methods:

• Fabrication of Copper 1,4-benzenedicarboxylate (CuBDC) HSA via in situ growth on stone paper (hydrolysis, anion exchange, heteroepitaxy).
• Characterization of the CuBDC HSA structure and morphology.
• Electrochemical sensing of ascorbic acid using the CuBDC HSA sensor.

Main Results:

• The CuBDC HSA exhibited a high sensitivity (396.8 μA mM⁻¹ cm⁻²) and a low detection limit (0.1 μM) for AA.
• The sensor demonstrated excellent selectivity, stability, and reproducibility.
• The CuBDC HSA sensor accurately detected AA levels in juice samples and showed feasibility for sweat analysis.

Conclusions:

• The novel CuBDC HSA architecture provides enhanced reactant dispersion, active sites, and charge transport for superior electro-oxidation of AA.
• This MOF-based sensor holds significant potential for noninvasive human health monitoring through accurate AA detection.