Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks

Cybergenetics is a new area of research aimed at developing digital and biological controllers for living systems. Synthetic biologists have begun exploiting cybergenetic tools and platforms to both accelerate the development of mathematical models and develop control strategies for complex biological phenomena. Here, we review the state of the art in cybergenetic identification and control. Our aim is to lower the entry barrier to this field and foster the adoption of methods and technologies that will accelerate the pace at which Synthetic Biology progresses toward applications.